Codeine: In individuals acquiring MAO inhibitors, an Preliminary smaller test dose is advisable to allow observation of any too much narcotic results or MAOI interaction.

Codeine is modified into a robust opioid drug (morphine) in Your system. In many people, this modification transpires a lot quicker and a lot more fully than regular, which improves the chance of very severe side effects.

Prolonged-time period animal studies haven't been executed to assess the carcinogenic opportunity of codeine or of promethazine, nor are there other animal or human details about carcinogenicity, mutagenicity, or impairment of fertility with these brokers.

Resuscitation may be necessary (see OVERDOSAGE). Restricted details counsel that usage of promethazine hydrochloride during labor and shipping and delivery does not have an considerable impact on the period of labor or shipping and delivery and would not increase the danger of require for intervention during the new child.

It is actually soluble in drinking water and freely soluble in Liquor. It has a molecular excess weight of 320.88, a molecular method of C17H20N2S•HCl, and the following structural components:

This product or service may perhaps comprise inactive elements, which could lead to allergic reactions or other troubles. Talk to your pharmacist for more aspects.

Promethazine is contraindicated in comatose states, and in people today identified being hypersensitive or to get experienced an idiosyncratic response to promethazine or to other

Promethazine and codeine ought to be utilized all through pregnancy provided that the potential reward justifies the likely danger on the fetus.

Respiratory melancholy bringing about arrest, coma, and death has happened with the use of codeine antitussives in youthful youngsters, especially inside the beneath-a single-calendar year infants whose ability to deactivate the drug is just not entirely formulated.

Will not flush drugs down the rest room or pour them right into a drain Except instructed to take action. Appropriately discard this products when it is expired or no longer required. Speak to your pharmacist or area waste disposal company.

Be sure you know the way to take this solution and what other medicine you ought to stay away from taking with it. See also Drug Interactions segment. Get professional medical assistance instantly if any of such quite really serious Unintended effects arise: gradual/shallow respiration, strange lightheadedness, severe drowsiness/dizziness, issues waking up.

Antihistamines and codeine are both of those contraindicated for use within the therapy of reduced respiratory tract signs and symptoms, such as asthma.

Promethazine is properly absorbed within the gastrointestinal tract. Clinical effects are apparent within just twenty minutes after oral administration and generally final 4 to 6 hrs, Whilst they may persist providing 12 several Promethazine codeine syrup hours.

This is very critical for aged individuals, who may be additional delicate to the effects of agony medicines. If an excessive amount of this drugs is taken for years, it may grow to be routine-forming (causing mental or Bodily dependence).